Professor Horch's research focuses on how neurons in adult invertebrates recover from injury. 不像许多神经系统, the auditory system of the cricket demonstrates robust neuronal growth in response to denervation. Removing one ear induces auditory interneurons to sprout new dendrites, 生长异常越过中线, form synapses with intact auditory neurons from the opposite ear. 目前, students in my lab are using molecular biology to clone the genes for guidance cues from crickets. We hope to examine the expression of these cues to assess if they might be involved in this regeneration. We are also examining the 3-dimensional characteristics of these regenerated neurons. The lab regularly uses techniques such as dye backfills, 免疫组织化学, 原位杂交, 聚合酶链反应, 还有共聚焦显微镜. We are also attempting to develop a method for transfecting living neurons in crickets.
新闻
- Six Women Scientists Receive Prestigious External Grants in Spring Semester, 皇冠体育新闻(2018年10月25日)
- 2017年莎拉和詹姆斯·皇冠体育日, 皇冠体育新闻(2017年10月)
- 霍希教授讲蟋蟀的重要性, 皇冠体育新闻(2017年5月1日)
学生实验研究样本
The 神经科学 department awards its outstanding students with the opportunity to do serious lab research over the Summer. Stipends are available and projects are often co-authored for publication. This Summer has again yielded outstanding original research in the filed. 以下是一些示例项目:
近期荣誉论文
艾丽西亚爱德华兹
Semaphorin-induced plasticity in the nervous system of the cricket, Gryllus bimaculatus.
撒母耳Brill-Weil
That’s DOPE: The delayed onset, prolonged excitation response of a primary auditory interneuron in Gryllus bimaculatus.
费利西亚王
Differential gene expression during compensatory plasticity in the prothoracic ganglion of the cricket, Gryllus bimaculatus.
朱莉·斯科尔斯
描述的 negative phonotactic 行为 in the adult cricket, Gryllus bimaculatus.
杰克·莫伊尼汉
Using a combined physiological recording and electrophoretic staining technique to better understand compensatory plasticity in Gryllus bimaculatus.
约翰·彼得罗
The role of dscam2 in neuronal regeneration in the auditory system of 普通蟋蟀 Gryllus bimaculatus.
香农的骑士
Determining the role of semaphorin proteins in the compensatory growth
成人观察 Gryllus bimaculatus.
玛迪鲁坦
Effect of injury on alternative polyadenylation of neuronal
蟋蟀的突触蛋白， Gryllus bimaculatus.
约翰·霍布斯
The effects of hormones on the sexual dimorphic auditory dendritic compensatory regeneration of the Cricket Gryllus bimaculatus.
亚当•张
Quantifying Changes in Semaphorin 经验值ression after Deafferentation in Gryllus Bimaculatus.
